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KMID : 1155520100050010020
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Anesthesia and Pain Medicine
2010 Volume.5 No. 1 p.20 ~ p.23
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Effect of remifentanil on tumor necrosis factor-alpha and interleukin-6 responses in patients undergoing laparoscopic hysterectomy
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Kim Eun-Sung
Ryu Keon-Hee
Park Hue-Jung
Chang Hae-Wone
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Abstract
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Background: Cytokines are important mediators of immune response to surgery and pain.The aim of the study was to investigate the effect of remifentanil on serum levels of cytokines, tumor necrosis factor-alpha (TNF-?) and interleukin-6 (IL-6), in patients undergoing laparoscopic hysterectomy.
Methods: Twenty four patients scheduled for laparoscopic hysterectomy were randomly assigned to control or remifentanil group.Both groups received 1.5?2.5% end tidal concentration of sevoflurane and air in 50% oxygen.Remifentanil group received a bolus of remifentanil 1?g/kg over 1 min and an infusion of remifentanil at a rate of 0.1?g/kg/min.Control group received 10 ml saline (placebo) and an infusion of saline at the same rate. Venous blood samples for measurement of serum cytokine concentrations were taken before anesthesia (T1), at 2 h after infusion (T2), and at the 1 hour after surgery (T3).
Results: Serum TNF-? concentration did not differ significantly over time in both groups.Serum TNF-? concentration was higher in remifentanil group at T3 (9.76 ± 1.19 pg/ml vs.8.53 ± 0.71 pg/ml) than in control group (P ＜ 0.05). In both groups, serum IL-6 concentrations were significantly higher at T3, when compared to those at T1 and T2 (P ＜ 0.05).
Conclusions: Remifentanil did not attenuate early postoperative change of serum TNF-? and IL-6 concentrations in patients undergoing laparoscopic hysterectomy. Serum IL-6 level increased at postoperative 1 h, regardless of remifentanil use.
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KEYWORD
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Interleukin-6, Remifentanil, Tumor necrosis factor-?
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